PL and GEL decreased (104 mmol/L, interquartile range 103-105 and 106 mmol/L, IQR 105-107.5, respectively), whereas HES increased the concentration of Cl- to 109 (IQR 108-110) mmol/L.
All fluids caused comparable degree of haemodilution. The test solutions included balanced crystalloid (Plasmalyte®, Baxter, Poland ), succinylated gelatin (Geloplasma®, Fresenius Kabi, Poland ) and 6% HES 130/0.4 (Volulyte®, Fresenius Kabi, Poland ). The whole blood was diluted in 4:1 ratio with the study solutions to make an end-concentration of 20 vol.% of each solution. Study group comprised 32 healthy male volunteers (without history of any acute/chronic disorder or known metabolic abnormality), aged 21-35 (29 ± 4) years, weight 59-103 (81.2 ± 9.8) kg, from whom blood samples were withdrawn. We sought to investigate the impact of three commonly used balanced fluids on electrolytes and metabolic equilibrium in an in vitro setting. There is a growing body of evidence that fluid therapy should be more individualised and preferably based on balanced solutions. Popular intravenous fluids in clinical use may have an impact on electrolyte concentration and metabolic balance and should be considered as powerful pharmacological agents. Does fluid resuscitation with balanced solutions induce electrolyte and metabolic abnormalities? An in vitro assessment.
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